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In addition, the P-loop arginine residue stabilizes the substrate phosphate group by forming salt bridge (a combination of hydrogen bonding and ionic bonding) interactions, followed by stabilizing the cysteinyl-phosphate intermediate

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In SK-N-BE cells, etorphine-induced hDOR desensitization is totally inhibited by using the dominant negative GRK2 mutant K220R but is only reduced when using PKC and tyrosine kinase inhibitors (Marie et al., 2008)