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Furthermore, it contributes to the accumulation of mutations in genes critical for cell cycle regulation and neuroendocrine differentiation, such as TP53 , RB1 , AKT1 , BCL-2 , and c-MYC , thereby facilitating the promotion of carcinogenesis in MCC [57, 58]

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Lupus is an autoimmune condition where the immune system attacks its own tissues, and this causes, as I mentioned earlier, a multisystem inflammatory process and tissue damage in the affected organs

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