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Scheffler A, Rauwald HW, Kampa B, Mann U, Mohr FW, Dhein S

Strengthening the understanding of metabolic comorbidities associated with psoriasis is of great significance for understanding the pathogenesis of psoriasis and developing novel therapeutic strategies

For the human orthotopic injection model, TS543 cells (10 5 cells in 2 L, passage 8) were injected in 8-week-old female nude mice (CrTac:NCr- Foxn1 nu , Taconic) using the same co-ordinates as above

LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes

Reduction of pyruvate decreased TCA cycle functionality, which was already impaired by mROS