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A meta-analysis confirmed that melatonin supplementation significantly increases TAC in PCOS patients (148)

PMID: 36403931 Cell Signal2021 Sep:85:110062

Epperson, C

it can be the difference between tolerating a supplement and having to abandon it

52,53 Enzymes such as protein kinase C (PKC), MAPK, and protein kinase A (PKA) modulate NOX activation, whereas the tumor suppressor p53 regulates both antioxidant and prooxidant responses, promoting ROS production and apoptosis in cancer cells