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The development of biomarkers that can reflect the state of ferroptosis in the brain is crucial for enabling early diagnosis, assessing disease progression and monitoring therapeutic responses (Table II)

In addition, in a rat renal ischemiareperfusion injury model, bardoxolone methyl decreased urea, creatinine, NGAL, total oxidant status, nitric oxide, and ADMA levels, increased SOD and GSH-Px activities, and upregulated renal Nrf2 and PPAR expression, suggesting that its anti-oxidative, anti-inflammatory, and anti-apoptotic effects collectively mitigate AKI severity (258)

Specifications Procurement-ready product data CAS 1415456-99-3 Molecular formula C194H312N54O59S2 Molecular weight 4409 Da Appearance Lyophilized powder or supplied format listed on batch COA Purity / identity 99% Common vial sizes 10mg*10vials 2mg*10vials 5mg*10vials Minimum order 1 unit

doi: 10.3389/fimmu.2020.623691 10 ZhangWZouGLiBDuXSunZSunYet al