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There is a particular need for human studies focused on the following: (i) validation of airway and systemic GSH/GSSG redox balance as a biomarker of asthma susceptibility, (ii) the natural history of GSH/GSSG redox balance in asthma across the lifespan, (iii) the specific role of GSH/GSSG redox balance in clinical manifestations of the disorder, including asthma severity and the response to secondary insults, (iv) the utility of GSH/GSSG redox balance as a predictor and indictor of asthma treatment responsiveness, and (v) therapeutic approaches to restore the GSH/GSSG redox balance in asthma and modify the course of the disorder

The pancreas releases enzymes needed to transfer vitamin B12 from its initial carrier protein to intrinsic factor in the duodenum

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PLoS Biol 16(5)