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Transcriptomic analysis revealed significant differences between expression signatures of Nrf2 WT and KO cells, showing 1,566 up-regulated and 5,272 down-regulated genes in the Nrf2 KO condition compared with the WT (Fig 6A)

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However, in individuals suffering from different neurodevelopmental disorder conditions, including ASD, these pathways can be hyperactivated, causing irreversible damage to the organism

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