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Similarly, cullin proteins indirectly interact with one of two RING domain containing proteins (Roc1/Rbx1 or Roc2/Rbx2) which in turn bind to E2 ubiquitin conjugating enzymes

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In the open-label, multicenter study, patients with SAH (MDF 32 and MELD score 35) were randomized to receive SOC with continuous ELAD therapy for 35 days or SOC alone