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Furthermore, the degree of senescence before kidney transplantation is capable of predicting the patients outcome regarding graft success [89], indicating that targeting senescent cells may be an efficient therapeutic strategy in renal diseases, and various studies have reported improved renal function and attenuated kidney fibrosis following decreased senescent cells

Moreover, HGF downregulates the expression of thrombospondin 1, which negatively regulates angiogenesis (Zhang et al., 2003