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This adaptability enables macrophage polarization, which is the process by which macrophages mount a specific phenotypic and functional response to the microenvironmental stimuli encountered in a specific tissue (Sica and Mantovani, 2012)

Kristensen for critical reading and J

Important Notes Skin whitening does not happen overnight and not all skin types respond exactly the same

Menadione can interfere with the function of glutathione, one of the body's natural antioxidants, resulting in oxidative damage to cell membranes

Conversely, GSTD3, GSTS5, and GSTS6 from the delta and sigma classes exhibited higher catalytic efficiency towards benzyl ITC than allyl ITC (Table 1)