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Associations between low consumption of fruits and vegetables and nutritional deficiencies in Brazilian schoolchildren

but the main source of cellular NADPH are two enzymes of the oxidative branch of the pentose phosphate pathway (PPP), 6-phosphogluconate dehydrogenase (6PG) and the PPP rate-limiting enzyme glucose-6-phosphate dehydrogenase (G6PD) (see Figure 1)

Then Lilly came along with #tirzepatide, a dual GLP-1 and GIP agonist, a molecule that didnt just improve glucose control but delivered an average 20% weight loss in clinical trials, compared to roughly 15% with Wegovy