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The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

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3.2.1 Background BD is a chronic psychiatric condition characterized by alternating episodes of depression and elevated mood states, which may manifest as mania or hypomania

Interestingly, surviving mature OLGs produce fewer new myelin sheaths than newly formed OLGs, but they better preserve the pattern of myelination in the cortex, with potential implications for functional recovery (Bacmeister et al., What Curbs Spontaneous Myelin Repair