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Long-term use of inhaled corticosteroids, especially at high doses, may contribute to decreased bone mineral density, increasing the risk of osteoporosis and fractures

Commenters stated that the policy could reduce access to care, particularly for high-cost new technologies such as innovative cell and gene therapies, and in rural communities

Type 2 NPIs are also known as organizational NPIs

The physics are similar

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects