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Porphyria comes from the Greek word porphyra, meaning purple pigment, which refers to the purplish glow the urine of porphyria patients emits when exposed to light (Signal, 1993)

British Journal of Clinical Pharmacology, 56: 635638

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Iron metabolism defines macrophage subsets, with M1 macrophages increasing iron retention to exhibit an iron-sequestering phenotype by upregulating ferritin and hepcidin and downregulating TfR1, FPN, and HO-1 expression, compared to M2 macrophages, which exhibit reduced iron levels (termed the iron-releasing phenotype) [68,69,70]