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Histological analysis reveals that aged kidneys accumulate senescent cells primarily in tubular regions, identified by loss of Lamin B1 (LMNB1), elevated senescence-associated -galactosidase activity, and expression of inflammatory IL-6

The findings revealed that irregular activation of HGF/c-MET enhanced TGF- release from cancer cells, reduced CTL penetration at the tumor site, and eventually caused immune evasion

Disruptions in mitochondrial function can lead to altered cellular energy metabolism, increased production of ROS, and impaired cellular responses to mechanical stress

L., Gayda-Chelder, C

That matters clinically because tendon and ligament recovery depends heavily on cellular repair activity, collagen organization, vascular support, and the ability to gradually reload tissue