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Reported approaches include LDM (Wellcomet, Germany) ultrasound for the mechanical dispersion of tissue and trapped blood components, PICO laser for pigment fragmentation, radiofrequency (RF) to soften the scaffoldtissue complex, long-pulsed Nd:YAG for targeting residual pigment molecules, IPL for vascular and pigment clearance, and an enzymatic strategy

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Vitamin D, in particular, not only alleviates OS but also exerts therapeutic effects by regulating key nodes in hormonal signaling pathways

doi: 10.1056/nejm197903083001002 87 HillGSDelahousseMNochyDRmyPMignonFMryJPet al