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However, BDNF/TrkB, via activation of many signaling pathways, promotes synaptic plasticity, dendritic growth, and other neuroprotective effects (Numakawa & Odaka, 2021)

Recent study demonstrated that the blockage of CLEC-2 (C-type lectin-like receptor-2) podoplanin axis reduces the hepatotoxicity and transaminase levels in AILI by increasing TNF- related recruitment of reparative hepatic neutrophils [87]

Another study found that selenium enhances GPX4 expression and total GPX activity, while knockdown of GPX4 by small interfering RNA increased vascular endothelial growth factor (VEGF) and Interleukin-8 expression (Rohr-Udilova et al., 2012)

Thus, we have exemplified a new site for the development of compounds to inhibit KRAS, together with a pharmacophore as a starting point for this approach

Cells were seeded into 6-well plates and cultured in complete medium