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In acute myeloid leukemia (AML), gold nanoparticles (AuNPs) were modified by encapsulating anti-miR-221 and adding to their surfaces DNA aptamer AS1411, which can interact specifically with nucleolin in AML cells, thereby targeting the nucleolin/miR-221/NF-B/DNMT1 signaling pathway responsible for leukemogenesis (Deng et al

& Natali, M

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The technique was developed in 1960s, with the first specialized SANS diffractometers being developed at the Jlich research center in Germany in the early 1970s (Jacrot, 1976)