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E1 and E2 enzymes: upstream regulators of cardiac ubiquitination capacity E1 activators: gatekeepers of the UPS pathway The UPS pathway begins with the activation of ubiquitin by E1 activators, also known as ubiquitin-like modifier activating enzymes (UBA1-UBA7)

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d) CAR-T Cell Therapy: Chimeric Antigen Receptor (CAR) T-cell therapy involves genetically modifying a patient's T cells to express receptors that target cancer-specific antigens

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