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This issue is addressed in the following section

Hypertension, an increased risk of bleeding, and gastrointestinal perforation are adverse effects associated with bevacizumab treatment (Wang 2013

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Funding This work was supported by Guizhou Provincial Science and Technology Projects (2018-1102)

The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior