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The HPA axis is a critical neuroendocrine system, and its hyperactivity is regarded as a key neurobiological feature of major depression

Direct Evidence for A Role of Redox Dysregulation in Als In this section, we discuss evidence demonstrating that the central cellular redox regulatory mechanisms and associated proteins are perturbed in ALS (Table 2)

2010;8:e1000479 Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, et al

Biomolecules, 9 (8), 356

As an inhibitor of NRF2, Keap1 recognizes and binds to the ETGE and DLG motifs of NRF2 via its Kelch repeat domain, thereby continuously suppressing and promoting the degradation of NRF2 [87]