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While Grn homozygous null ( Grn / ) mice are viable and fertile, they exhibit several features of FTLD- GRN and CLN11 including lysosomal dysregulation, lipofuscinosis, neuroinflammation, synaptic loss, retinal ganglion cell (RGC) loss, and obsessive compulsive disorder (OCD)-like behavior as well as social deficits [16, 88, 137, 174,175,176,177] and therefore have been widely used as a model of FTLD- GRN and CLN11

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Detoxification Supports the liver in removing toxins from the body

GPx activity is stable or reduced during CD remission and increases during active CD (157)