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Emerging PTMs such as SUMOylation, O-GlcNAcylation, lactylation and succinylation have recently been implicated in redox regulation and metabolic stress adaptation in other disease contexts

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Various plasmatic cytokines and inflammatory markers in patients with AMN were reduced after multi-antioxidant combination therapy, among which inflammatory markers, such as monocyte chemoattractant protein-1 (MCP1) and 15-hydroxyeicosatetraenoic acid (15-HETE), were significantly downregulated to become the promising predictors of response to treatment ( In brief, these redox imbalances and inflammatory markers observed in the blood may be potential predictors of X-ALD, providing a reliable basis for disease severity, progression, as well as therapeutic response

Proc Natl Acad Sci 79:62466249 Wu X, Liang H, OHara KA, Yalowich JC, Hasinoff BB (2008) Thiol-modulated mechanism of the cytotoxity of thimerosal and inhibition of DNA topoisomerase II alpha

& Yamamoto, A