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Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

It has been determined that the a -tocopherol is the most suitable antioxidant and protect the membrane from oxidation by reacting with the various lipid radicals generated in the peroxidation chain reaction of lipid

The IF staining and Western blot analyses for -H2AX, a marker for DNA double-strand damage, and phosphorylated nucleophosmin 1 (pNPM1) required for DNA damage repair were performed in RSL3-treated K1 cells

doi: 10.1093/oxfordjournals.aje.a113632 61 HuT-sLaoY-x

As an example, they constructed Sandwich-type polyoxotungstate nanoclusters (termed Fe 4 Se 2 W 18 NCs) for GSH depletion-sensitized RT