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Original Articles Basic and Translational Research LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBP Axis Lei Zhou, Yuwen Jiao, Jiaming Xue, Xiaoqiang Zhan, Dongmei Wang, Liming Tang Received March 4, 2025 Accepted July 24, 2025 Published online November 12, 2025 DOI: [Epub ahead of print] 1,735 View 61 Download 2 Crossref Abstract PDFSupplementary MaterialPubReader ePub Background To investigate the biological functions of the transcription factor LRR binding FLII interacting protein 1 (LRRFIP1) in white adipocyte differentiation (WAD) and elucidate the underlying molecular regulatory mechanisms involved

This resulted in a decrease in ICDH activity and negative regulation of the TCA cycle, thereby activating the oil accumulation pathway at an early stage

Mitochondrial-Nuclear Communication: Under conditions of metabolic stress or exercise, MOTS-c translocates to the nucleus, where it regulates the expression of nuclear genes associated with stress adaptation and homeostasis

lactis HN019 in pregnant mice attenuated periodontitis-induced intestinal damage, systemic inflammation, and adverse pregnancy outcomes like fetal growth restriction ( Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in diabetic mice via gut microbiota regulation (Zhang et al., 2023a)