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Johns wort can cause (the potentially life-threatening) serotonin syndrome when taken with SSRIs

In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolonged coma and with a higher incidence of gastrointestinal bleeding and pneumonia

For severe deficiencies, healthcare providers might recommend higher doses through injections

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[10] PA may be suspected when a patient's blood smear shows large, fragile, immature erythrocytes, known as megaloblasts