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Scand J Pub Health 2001;29:3007

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This increase in reactive oxygen species results in depletion in alveolar levels of the key antioxidant glutathione (GSH) and increases in alveolar oxidized glutathione (GSSG), a phenomenon seen both in animal models and humans who abuse alcohol

In bladder tissue from patients with IC/BPS, non-Hunner-type IC has been shown to cause fibrosis and mast cell infiltration, whereas Hunner-type IC caused urothelium denudation and inflammation 12