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The requirement for T4 is likely to increase in hypothyroid patients who become pregnant or who are commenced on anticonvulsants or oestrogen containing oral contraceptives

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Nevertheless, despite this strong cell cycle phenotype and being the first described F-box protein in higher eukaryotes, Cyclin F went a long time without having a bona fide substrate

Collectively, age-related inflammatory states, OS, metabolic disorders, and environmental pollutants appear to contribute to ovarian dysfunction by inducing pyroptosis in granulosa cells (Figure 5B)

10.1146/annurev.pharmtox.45.120403.095857 31 HayesJ