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10.1152/japplphysiol.01337.2009 41 DellaliM.BarelliM

Atkuri KR, et al

These effects protect cells from oxidative stress and enhance tissue recovery in injured or aging tissues 3

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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19