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82 Tunnicliffe WS, O'Hickey SP, Fletcher TJ, Miles JF, Burge PS, Ayres JG

1 2 Chest

The in vivo study verified these findings, showing increased LC3 and decreased ROS levels in the kidney of mice on a ketogenic diet [97]

Once sealed, the autophagosome undergoes a maturation process involving the dissociation of ATG components and removal of PI3P, preparing it for fusion with lysosomes through the actions of Rab GTPases, SNARE proteins, and tethering complexes