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Licorice Extract a soothing, natural ingredient often included for its calming and brightening properties

Johns wort may help alleviate depression in people with fibromyalgia

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J Trace Elem Med Biol 64:126680 Zhang Y, Wu Q, Zhang L, Wang Q, Yang Z, Liu J et al (2019) Caffeic acid reduces A53T -synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinsons disease

Its since become one of the most studied metabolic peptide fragments in preclinical research