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In the 1990s he became interested in the connection between DNA damage and cancer, inflammation, and oxidative damage, which led to further ideas about poor quality diets and micronutrient deficiency being a major contributor to DNA damage and cancer

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Key mechanisms include improved insulin sensitivity/secretion (increased HOMA- [57]), reduced hyperglycemia [51, 56], amelioration of oxidative stress [52, 53], and reduced inflammation [52]

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