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This change is connected with a displacement of the Phe 23-Tyr 24-Phe 25-Asn 26 beta-strand-like segment, i.e., of aromatic side chains known to be important for receptor binding

Damage-associated molecular patterns (DAMPs) are of particular interest, as they can trigger the inflammatory response observed in the active stage of vitiligo, with a series of DAMP-associated proteins existing in vitiligo.4 The DAMP with the most evidence of association with vitiligo is heat shock protein 70 (HSP70), which belongs to the family of intracellular chaperones whose function is to prevent incorrect protein folding

Alogliptin (15 mg/kg/d for 24 weeks) decreased the atherosclerotic lesions and declined the elevated expressions of inflammatory markers IL-1 and IL-6 in ApoE-/- diabetic mice

Poon HF, Hensley K, Thongboonkerd V, Merchant ML, Lynn BC, Pierce WM et al

doi: 10.1084/jem.20052398 46 McDevittM