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The crosstalk between hepcidin-SLC40A1 mediated system iron metabolism and IRP-IRE regulated cellular iron homeostasis is that the IRP-IRE system senses cellular iron starvation and limits iron losses, whereas hepcidin-FPN protects the organism against systemic iron overload

Inflammation disrupts estrogen signaling, increases stress hormones, and heightens digestive and emotional symptoms Vellura targets these pathways

On one hand, gut-to-lung axis: Circulating gut-derived metabolites (e.g., tryptophan catabolites) directly regulate pulmonary epithelial immunity

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Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R