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SH-SY5Y represent an excellent model for testing neurotoxicity 37,38 similar to the TG9G cell line

Brain MDA or GSH were not significantly altered by fluoxetine, sertraline or imipramine alone (Figs

Lignans from sambucus williamsii protect bone via microbiome

Other preclinical investigations demonstrated positive benefits of SF on AD by attenuating A oligomers-mediated reduction of phagocytic activity (5 M for 24 h) (72), reducing streptozotocin-induced cognitive deficits (141 or 282 mol/kg/day for 6 weeks) (73), decreasing neuroinflammation and inhibiting tau phosphorylation (1 or 2 M for 1 h and stimulated with LPS for 23 h) (73), and reducing A production (226 mol/kg three times a week for 4 weeks) (74) in in vivo and in vitro AD models

Barite is a denser mineral (BaSO 4 = 4.5 g/cm 3 ) than either celestite (SrSO 4 = 3.96 g/cm 3 ) or calcite (CaCO 3 = ~2.8 g/cm 3 )