Some free radicals, particularly the hydroxyl radical (OH) are very toxic to the tissues
The compound of 3 is (a) 4- to 7-membered heterocyclyl containing 1 or 2 heteroatoms independently selected from N, O and S, (b) 5- or 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O, and S, (c) (C 1-6 )alkyl-heteroaryl, wherein the heteroaryl is a 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently selected from N, O and S, (d) (C 1-6 )alkyl-aryl, (e) (C 1-6 )alkyl-heterocyclyl, wherein the heterocyclyl is a 3- to 6-membered ring containing 1 or 2 heteroatoms independently selected from N, O and S, (f) (C 1-6 )alkyl, (g) (C 3-6 )cycloalkyl, (h) (C 3-6 )cycloalkyl-heterocyclyl wherein the heterocyclyl is a 3- to 6-membered ring containing 1 or 2 heteroatoms independently selected from N, O and S, or (i) (C 1-6 )alkyl-S(O) 2 NR 8a R 8b , (j) C( 1-6 )alkyl-OC 1-3 alkyl, or (k) C( 1-6 )alkyl-OC 3-6 cycloalkyl, wherein each aryl, fused aryl, heteroaryl, cycloalkyl, or heterocyclyl is unsubstituted or substituted with 1, 2, or 3 R 9 , and wherein each alkyl is unsubstituted or substituted with 1, 2, or 3 R 10
Hegewisch Becker S, Smith M, Redner A, Wisniewski D, Clarkson B, Andreeff M
261 Lysosomal dysfunction is considered a critical factor in the development of many diseases, 261 which may manifest as impaired acidification, abnormal expression of lysosomal enzymes, lysosomal membrane stability issues, transport defects, and defects in autophagosome/endosome-lysosome fusion
NAPstar3 and 4.3 were chosen as their different K r(NADPH/NADP+) was expected to allow us to cover a broad-range of plausible cytosolic NADP redox states
