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First-pass hepatic metabolism degrades an unknown percentage of orally administered 5-Amino-1MQ before it reaches systemic circulation, introducing dosing variability that conflicts with controlled study design

Symptoms of vitamin B12 deficiency Symptoms tend to develop slowly and may not be recognized immediately

Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L

Loading phase (deficiency): 1000 mcg IM or subQ daily or every other day for 1 to 2 weeks Maintenance: 1000 mcg monthly is a standard maintenance dose for conditions like pernicious anemia Wellness protocols: may use lower doses weekly, though this is less established clinically In ml: cyanocobalamin is typically supplied at 1000 mcg/ml, so a 1000 mcg dose equals 1 ml

This increases neurodegenerative conditions in the body leading to dementia and often times peripheral neuropathy