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Likewise, ATF6 enhances cytoprotective UPR genes such as Grp78 and Xbp1 during acute stress, but under chronic lipotoxicity, it preferentially targets inflammatory and lipid metabolic genes to amplify macrophage inflammation (156)

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reported that SNO modification of Cys833 and Cys839 increased ubiquitination and promoted the degradation of LTBP1