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Description

PLoS ONE 9 , e116386 (2014)

An intravenous dose of 3.25 mg/kg resulted in a methaemoglobin concentration of 30% in 10 min, a methaemoglobin level of 15% being reached within one min

These findings have stimulated clinical development attempts, particularly for NAD + modulators deemed suitable for human trials in terms of safety and upscaling, such as natural precursors