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Nrf2-deficient mice exposed to CS had more extensive emphysema and more pronounced airway inflammation than wild-type mice

While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression

Apigenin also preserves hippocampal synaptic plasticity and upregulates BDNF, contributing to its nootropic effects post-TBI

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Patients were followed for 1 year with an initial assessment of the underlying liver disease with Fibroscan and thereafter visited every 3 months by the psychologist