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However, multiple factors during dialysis, such as poor biocompatibility, contaminated dialysis water, and immunosuppressive therapy, lead to proinflammatory and prooxidative effects that may adversely affect the aging process (Sturmlechner et al., 2017)

Annals of the Rheumatic Diseases

Randomized controlled trials (RCTs) report that IF reduces androgen markers, including total testosterone and free androgen index, in premenopausal females with obesity, while producing modest declines in testosterone among lean males without significantly affecting LH secretion [55]

2235 As the mechanisms involved in antioxidant-enzyme interactions are better understood, more information about cellular defense systems and potential therapeutic interventions will emerge

Oxidative stress results from an imbalance in redox homeostasis between oxidative and antioxidant systems, which adversely affects all renal components (24)