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The extended half-life enables once-weekly subcutaneous dosing, which is the standard clinical approach [1]

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With 100 mg/mL, 0.3 mL = 30 mg (because 100 mg 0.3 mL = 30 mg )

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Moreover, experiments are often performed under supraphysiological pressures [47,48,49] that are orders of magnitude larger than those sensed by tumor cells in vivo

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Inflammatory cytokines and enzymes, such as interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor-alpha (TNF-), nitric oxide (NO), inducible nitric oxide synthase (iNOS), and matrix metalloproteinases (MMPs), show a high correlation with the pathogenesis of hemorrhoids

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