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Meanwhile, transgenic probes such as roGFP (1&2) and HyPer exhibit altered fluorescence when oxidised by intracellular H 2 O 2 [16,17]

Necrotizing mediastinitis: decreasing mortality through a systematic approach

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demonstrated that EGFR inhibitors could also promote TNF receptor-associated factor 2 (TRAF2) ubiquitination and its association with RIP1/TAK1, inducing activation of the NFkB typical pathway and NFkB transcriptional targets (86)

Therefore, therapeutic strategies should aim at reducing free-radical formation, and at improving clearance