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For example, cimetidine acts as an OCT2 inhibitor that inhibits the transportation of cisplatin in the kidney to protect against AKI [64], carvedilol works as an antioxidant against the oxidative stress process [65], cilastatin inhibits the apoptotic pathway [66], and rosiglitazone reduces inflammation [67]

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Sun X, Wang M, Wang M, Yao L, Li X, Dong H, et al

doi: 10.1086/508434

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The study also revealed that CMF increased the synthesis of Th1 cytokines, such as IL-2 and IFN-, resulting in a substantial improvement in cell-mediated immunity