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For the other three assessment tools, the supplement group also had a slightly greater improvement than did the placebo group, but the effect was not significant

PGLS activity was assayed spectrophotometrically in a coupled enzyme assay by measuring the reduction of NADP + to NADPH during breakdown of 6PG produced by PGLS from -gluconolactone in presence of 6-phosphogluconate dehydrogenase as previously described (32)

The transmembrane 6 superfamily member 2 (TM6SF2) protein is mainly expressed in the liver and plays a key role in the maintenance of lipid homeostasis by controlling the secretion of lipids from the liver [266]