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In disorders such as multiple sclerosis, glutamate is thought to stimulate production of autoreactive T cells (Ganor and Levite, 2014), which may be due to stimulation of AMPA glutamate receptors on the cell surface (Ganor et al., 2007)

Furthermore, activated caspase-1 (CASP1) cleaves gasdermin D (GSDMD) into its N-terminal fragment (N-GSDMD), which forms membrane pores and initiates pyroptosis

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Spinal Conditions: Issues like herniated discs or spinal stenosis can compress nerves