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Elution fractions were buffer exchanged into 20 mM Tris-HCl at pH 8.0 and 50 mM NaCl using PD10 desalting columns (GE Life Sciences)

In macrophages infected with Leishmania donovani , activation of PINK1/Parkin-mediated mitophagy reduces mtROS accumulation and prevents uncontrolled inflammasome activation ( 5.5 Parasite-induced mitochondrial signaling and immune evasion Mitochondria orchestrate several innate immune pathways critical for parasite control, including NLRP3 inflammasome activation and type I interferon responses

While it is naturally synthesised by the liver and kidneys, it can be provided by supplementation

Colonna, M

These findings highlight the important role of IL-6 in regulating inflammatory processes while also emphasizing that other factors, such as fat accumulation, must still be considered