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Therefore, to accurately Ratio 2.2 indicates defi- measure vitamin E status, ratio of vitamin E : total Plasma alpha-toco- ciency lipids is used pherol (mol/l)/ Normally, 90% of total vitamin E is alpha-tocopherol plasma cholesterol Levels 10 mol/l gen- (mmol/l) erally indicate deficiency Plasma alpha-toco- pherol Vitamin K Normal levels are 0.45.0 Plasma vitamin K nmol/l Prothrombin time and/or clotting fac- Normal prothrombin time Because of the central role of vitamin K in blood coa- tors (X, IX, VII, and protein C) is 1114 sec

2 of 18 Journal of Biomedical Materials Research Part A, 2026 resulting in oxidative stress and tissue damage [6]