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It was FDA-approved in 1997 as Geref Diagnostic for testing pituitary function, and its therapeutic form (Geref) was used for pediatric growth hormone deficiency

Selectivity of 1D228 for 76 kinases based on HTRF and ADP-Glo methods: The compound was serial diluted from 10 mM stock in DMSO, dilute the test compound to 0.1 mM (200 times the specified test concentration)

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FOXO4-DRI (25 M

Phosphorylated -catenin translocates to the nucleus, binds to TCF/LEF transcription factors, and promotes the expression of many target genes, including those involved in cell proliferation, anti-apoptosis, invasion, and angiogenesis (Fig