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An altered mitochondrial Ca 2+ buffering may lead to prolonged elevation of intracellular Ca 2+ levels, activating various enzymes that can damage cellular structures and contribute to the inflammatory response

Specifically, BDNF contains sorting motifs in the pro domain region and mature region that can interact with the sorting receptors CPE and sortilin [9, 41, 53]

However, its poor solubility restricts its bioavailability for topical use

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